Coronary Artery Disease Risk Factors in Patients on Continuous Ambulatory Peritoneal Dialysis

AIM: We aimed to investigate especially early stage non traditional cardiovascular risk factors in end stage renal failure patients who were in Continued Ambulatory Peritoneal Dialysis (CAPD) programme in our center.

METHODS: In this study 21 CAPD patients and 21 sex and age matched controls were enrolled. The clinical history and demographic parameters were obtained and than for physical evaluation blood samples were drawn for 12 hours fasting glucose, serum total cholesterol, HDL- cholesterol, LDL- cholesterol, triglyceride, apoA, apoB, total protein, albumin, calcium, phosphorus, parathormon (PTH), hemoglobin (Hb), Lp(a), C-reactive protein (CRP), homocysteine (tHcy), anticardiolipin antibody (ACLA), fibrinogen.

RESULTS: While age, sex, Body Mass Index (BMI), smoking status and hereditary factors were comparable between the groups, diabetes mellitus and hypertension were significantly higher in CAPD patients. There was no statistical significance between the groups considering mean serum total cholesterol, HDL- cholesterol, LDLcholesterol, triglyceride, PTH, Lp(a), tHcy, ACLA Ig M and ACLA Ig G levels. In the present study mean apoA level was significantly lower in the study group, while apoB and phosphorus were higher (p=0.003). Also mean total protein, albumin, calcium, and Hb level were significantly lower, while mean CRP and fibrinogen were higher in the study group (p=0.0003).

CONCLUSION: Because of the high rates of increased risk factors for coronary artery disease in CAPD patients at early stages, these patients should be closely followed for coronary artery disease.