Comparison of sodium bicarbonate capsules and gastro-resistant sodium bicarbonate tablets in patients with stage 4 CKD

Objective: In this study, we aimed to compare stage 4 CKD (Chronic Kidney Disease) patients who received sodium bicarbonate treatment in the form of 500 mg capsules and 1000 mg gastro-resistant tablets.

Materials and Methods: All patients with stage 4 CKD admitted between August 2020 and November 2020 were evaluated retrospectively. The patients were divided into two groups as sodium bicarbonate group (SB) and gastro-resistant sodium bicarbonate group (GRSB). Groups were compared in terms of serum bicarbonate and side effects during follow-up.

Results: A total of 43 stage 4 CKD patients were included in this study. The bicarbonate change in both groups was statistically significant after the first week (p<0.001). In gastro-resistant sodium bicarbonate group bicarbonate level was significantly higher than sodium bicarbonate group on 1st week (p<0.001).

Conclusion: GRSB seems to normalize serum sodium bicarbonate earlier than SB.

Cite this article as: Kazan ED, Kazan S, Tunca O, Akgol J, Ulu S. Comparison of sodium bicarbonate capsules and gastro-resistant sodium bicarbonate tablets in patients with stage 4 chronic kidney disease. Turk J Nephrol. 2022;31(4):295-300.