Comparison of Modification of Diet in the Renal Disease (MDRD) and Cockroft-Gault (CG) Formulas for Estimating Glomerular Filtration Rate (GFR) in Patients Metabolic Syndrome

OBJECTIVE: Comparison of Glomerular Filtration Rate (GFR), by Cockroft-Gault (CG) and Modification of Diet in the Renal Disease (MDRD) formulas in metabolic syndrome patients.

MATERIAL and METHODS: 999 patients attending hypertension unit were studied retrospectively. 627 patients had MS parameters. MS was diagnosed according to the International Diabetes Federation. Renal function calculated with two formulas with creatinine, age, gender and Weight. Analysis was performed using SPSS 15.0. The significance level was P<0, 05.

RESULTS: Many patients were MS 627 (63%); non MS 372 (37%). In comparison MDRD and CG ; the proportion, according GFR < 60 ml/min/1.73 m2, in MS was high (p=0.015). In MS concerning of GFR were significant (p<0.001), in non MS was not different (p=0.027). In MS we observe a negative correlation between MDRD and uric acid (p<0.001), with CG it was not (p=0.555), between MDRD and albuminuria was not observed a correlation (p=0.263), with between CG and albuminuria there was an incorrect positive relationship.

CONCLUSION: In patients with MS, we recommend using the MDRD equation to predict Evaluation of glomerular filtration rate from serum creatinine concentration, because it is the most accurate in population MS and easily applicable in clinical practice.