Clinical Course of Kidney Donors in the Long Term after Transplant: A Single-Center Experience

Objective: The aim of this study was to evaluate the parameters affecting the long-term results and glomerular filtration rate (GFR) of kidney donors for five years and over.

Materials and Methods: Forty-two female and twenty-one male patients were included in this study. The mean age was 54.97±10.28 years and the mean follow-up time was 8.02±4.43 years. In our retrospective study, the follow-up period of the donors, age, sex, weight, height, hypertension (HT), coronary artery disease (CAD), diabetes mellitus (DM), drug use, cigarette and alcohol consumption, socio-economic status, educational level, and laboratory results was recorded. The patients were divided into three groups based on HT. Those diagnosed with HT before transplantation, those diagnosed with HT after transplantation, and those with normotensives.

Results: No correlation was found between GFR and gender, BMI, follow-up period (p<0.05 for all). Significant decrease in GFR was detected in HT group before transplantation (GFR 53.12±12.08 mL/min) compared with normotensive group (62.68±9.70 mL/min) (p=0.021). There was a positive correlation between age and uric acid (r=0.362, p<0.01). However, GFR correlated inversely with age and uric acid (r=-0.514, p<0.01; r=-0.364, p<0.01, respectively). When we performed multivariate regression analysis of age, uric acid, and blood pressure groups for GFR, only age was detected significantly as an independent risk factor (p<0.001).

Conclusion: For kidney donors, age and uric acid have a correlation with GFR. Only age is an independent risk factor for GFR.

Cite this article as: Atılgan KG, Aylı MD. Clinical Course of Kidney Donors in the Long Term after Transplant: A Single-Center Experience. Turk J Nephrol 2020; 29(3): 226-31.