Baseline Demographic, Clinical and Laboratory Parameters Related with 24 Hour Urinary Sodium Excretion in Newly Diagnosed Patients with Type 2 Diabetes

OBJECTIVE: Hypertension is very frequently observed in patients with Type 2 diabetes. Increased salt intake has been shown to be related with elevated blood pressure. However, factors related with 24 hour urinary sodium (Na) excretion as a measure of Na intake is not specifically addressed in patients with newly diagnosed Type 2 diabetic patients.

MATERIAL and Methods: All patients underwent history taking, physical examination, blood pressure measurement, electocardiography, biochemical analysis, spot urine analysis, 24-hour urine collection to measure 24-hour urinary albumin, protein, sodium excretion and creatinine clearance.

RESULTS: In total, 114 patients were enrolled. Spearman correlation analysis revealed that 24-hour urinary Na excretion was correlated with body mass index (BMI) ( rho: 0.265, p: 0.004). blood urea nitrogen (rho: -0.210, p: 0.025) creatinine clearance (rho: 0.313, p: 0.001), albumin (rho: 0.320, p: 0.001), hemoglobin (rho: 0.242, p: 0.013) and triglyceride (rho: 0.261, p: 0.008). Linear regression of independent factors revealed that BMI (B: 0.013, CI: 0.004-0.022, P: 0.004), presence of smoking (B: 0.132, CI: 0.02-0.243, P: 0.021), creatinine clearance (B: 0.002, CI: 0.001-0.004, P: 0.012), and triglyceride levels (B: 0.017, CI: 0.009-0.056, P: 0.003) were related with logarithmically converted 24-hour Na excretion.

CONCLUSION: We demonstrated that BMI, creatinine clearance and serum triglyceride levels were independently associated with 24-hour urinary Na excretion in newly diagnosed Type 2 diabetic patients