Henoch-Schönlein (HSP) purpura is a small vessel vasculitis affecting the skin, joint, gut, and kidneys. Azathioprine is a drug used to prevent rejection after solid organ transplantation and treat autoimmune-inflammatuar diseases. It has been reported that corticosteroid and AZA have some useful effect in HSP nephritis without renal dysfunction. AZA-associated side effects such as myelosupression, hepatotoxicity, pancreatitis, skin rash, fever, nausea, and abdominal pain often develop during the therapy. We report a case of alopecia as a rare complication of AZA therapy.