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Background: Diabetic kidney disease (DKD) is a severe issue that leads to end-stage kidney failure. Triglyceride Glucose (TyG) Index and CD36 are markers of insulin resistance, as well as renal resistivity index (RRI), are potential indicators of the severity of DKD. The role of TyG index TyG index and CD36 associated with DKD and their impact on its progression across various GFR categories (G1-G5), which can be assessed through RRI.
Methods: A cross-sectional study was performed on 75 type 2 DKD patients and 15 healthy participants with an average age of 35 and 60 years. Furthermore, HbA1c, FPG, TG, creatinine, eGFR, albumin creatinine ratio (ACR), and CD36 were measured. Additionally, TyG index was calculated. The RRI was evaluated with Doppler ultrasound.
Results: TyG index, CD36, and RRI all showed statistically significant increases when comparing the various categories of DKD to the healthy control. Additionally, they demonstrated a progressive and significant increase in each of these parameters from DKD G1 to G5 (P value < .001). The TyG index exhibited a significant positive connection with CD36 and RRI (P value < .001). The optimum cutoff values for TyG index, CD36, and RRI to differentiate between G1 patients and control were 8.45, 112.55, and 0.48, respectively, and AUC were 0.92, 0.92, and 0.918, respectively. These parameters could help in the early detection of DKD. BMI increased with worsening of DKD, and it showed a significant positive correlation with TyG index and sCD36.
Conclusion: TyG index, sCD36, and RRI are involved in the early diagnosis and may be used for the assessment of DKD progression in type 2 obese patients.
Cite this article as: Mahmoud Ibrahim H, Fooz N, Morad H, Shaker O. Association between triglyceride glucose index and soluble CD36 for early detection and progression of diabetic kidney disease evaluated by renal Doppler resistivity index. Turk J Nephrol. 2025;34(3):169-178.