Turkish Journal of Nephrology
Original Article

Association Between Elevated Serum Uric Acid and Vitamin D Insufficiency Among the Middle-Aged and Elderly Population

1.

İstanbul Medeniyet University, Department of Endocrinology, Göztepe Education and Research Hospital, İstanbul, Turkey

2.

Sakarya University Education and Research Hospital, Department of Nephrology, Sakarya, Turkey

3.

İstanbul Medeniyet University, Department of Biochemistry, Göztepe Education and Research Hospital, İstanbul, Turkey

4.

İstanbul Medeniyet University, Department of Internal Diseases, Göztepe Education and Research Hospital, İstanbul, Turkey

5.

İstanbul Medeniyet University, Department of Nephrology, Göztepe Education and Research Hospital, İstanbul, Turkey

6.

Konya State Hospital, Department of Nephrology, Konya, Turkey

7.

University of Colorado, Department of Renal Diseases and Hypertension, Aurora, USA

8.

Koç University Faculty of Medicine, Department of Nephrology, İstanbul, Turkey

Turkish J Nephrol 2016; 25: 182-186
DOI: 10.5262/tndt.2016.1002.10
Read: 930 Downloads: 506 Published: 05 February 2019

OBJECTIVE: Vitamin D insufficiency might have a role in numerous diseases including autoimmune disease, cancer, diabetes mellitus, hypertension and heart diseases. The relationship between vitamin D insufficiency and hyperuricemia has been shown previously but there are conflicting results in studies.

MATERIAL and METHODS: A total of 1562 patients who had serum uric acid and vitamin D levels measured at the same time were enrolled. Patients who were on vitamin D replacement therapy, receiving calcium and/or allopurinol, or had gout and chronic kidney disease were excluded.

RESULTS: Hyperuricemic patients had significantly lower levels of serum vitamin D level compared with normouricemic patients (p<0.001) whereas there was no difference between the groups in terms of serum calcium, phosphorus, parathormone and alkaline phosphatase. Severe deficiency (25(OH) vitamin D <10) was significantly more common among patients with hyperuricemia (p<0.001). When vitamin D levels were analyzed according to age, a significant inverse correlation between vitamin D and serum uric acid level was found in decades 7 and 8. Age, eGFR and vitamin D level below 20 appeared as independent associates of serum uric acid levels.

CONCLUSION: These data suggest that hyperuricemia associates with vitamin D deficiency. Further studies are needed to understand the mechanism underlying this association and its potential clinical implications. 

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