In renal transplant patients, acute pancreatitis is an unusual complication and mortality and morbidity of it is much higher than that of normals. Six years after transplantation, a 22-year-old man developed acute pancreatitis due to bilier lithiasis and acute renal failure. His condition improved dramatically with conservative theraphy and his renal function regressed to baseline levels. Elective cholecystectomy was performed three weeks later. We discussed the side effects of immunosuppressive drugs regarding acute pancreatitis and to highlight the beneficial effect of gallstone screening in renal transplanted patients.