Tubulointerstitial nephritis and uveitis syndrome is characterized by a combination of acute tubulointerstitial nephritis and uveitis. It is thought to be an autoimmune disease. Currently, 200 cases have been described in the literature. Most patients with this syndrome are young women and adolescents although it may occur in adults and older patients. In this report, we describe two patients with the TINU syndrome who were followed-up at our hospital.