Leptospirosis is a zoonotic infection, caused by Leptospira interrogans. Clinical presentation may vary from asymptomatic infection to Weil disease characterized by multiple organ failure. We described a 22-year-old case who had renal, hepatic and pulmonary involvement with leptospirosis. He presented with hyponatremia and recovered by the treatment with penicillin G. We emphasized that early diagnosis and management will be life saving.