Postpartum necrosis of pituitary gland is one of the most common reasons of hypopituitarism. It is most commonly due to massive bleeding before or during delivery. Nonspecific symptoms like fatigue and weakness may confuse and delay the diagnosis. Patients with Sheehan’s syndrome may rarely present with hyponatremia signs. A 55-year-old woman admitted to our nephrology department with stupor, severe hyponatremia (100 mEq/L), and hypoglycemia (56 mg/L). The diagnosis of Sheehan’s syndrome was based on medical history, laboratory and radiological imaging findings. The patient’s clinical picture improved dramatically after hormone and sodium replacement therapy. Sheehan’s syndrome must be in differential diagnosis of old women with hyponatremia and it must be known that hyponatremia in those patients may be severe.