Turkish Journal of Nephrology

25 (OH) Vitamin D in Patients with Chronic Kidney Disease and Dialysis Patients


İnönü Üniversitesi Tıp Fakültesi, Nefroloji Bilim Dalı, Malatya, Türkiye

Turkish J Nephrol 2012; 21: 211-216
DOI: 10.5262/tndt.2012.1003.02
Read: 722 Downloads: 414 Published: 12 February 2019

In addition to its role on calcium homeostasis, vitamin D exhibits local (paracrine) effects on cell proliferation differentiation and immune function. Most cells in the body express Vitamin D receptors and 1α-hydroxylase, thereby permitting local production of 1,25 dihydroxycholecalciferol, which has therapeutic implications (paracrine effects). Studies have shown that chronic vitamin D deficiency may have serious adverse consequences such as increased risk of hypertension, multiple sclerosis, rheumatoid arthritis, cancer of the colon, prostate, breast, ovary, and type 1 diabetes. However, information about the effect of vitamin D supplementation and replacement, and cardiometabolic outcomes is very limited. Studies on Vitamin D replacement in patients with chronic kidney disease and dialysis patients are needed.

EISSN 2667-4440