Turkish Journal of Nephrology
Original Article

The Relatıonship Between Urotensin-II Level and Carotid Intima Media Thickness in Dialysis Patients

1.

Department of Nephrology, Ankara Training and Research Hospital, Ankara, Turkey

2.

Department of Radiology, Ankara Training and Research Hospital, Ankara, Turkey

Turkish J Nephrol 1; 1: -
Read: 307 Published: 02 December 2021

Objective: The most important cause of mortality in patients with CKD is cardiovascular disease(CVD). Despite traditional risk factors being controlled, the lack of a desired reduction in mortality rates has led to investigate on new treatment strategies. In experimental studies, U-II has been shown to increase foam cell formation, reactive oxygen radicals, oxide-LDL levels, matrix-metalloproteinase expression; and thus, contributing to the development of atherosclerosis. The aim of the study was, to investigate the relationship between U-II and carotid intima media thickness(CIMT) in dialysis patients.

Material-methods: Thirty three hemodialysis(HD) patients, 35 peritoneal dialysis(PD) patients, 15 healthy individuals were included in the study. Patients with traditional risk factors for the development of cardiovascular disease, such as diabetes mellitus, familial hypercholesterolemia, and a family history of early cardiac disease, were not included in the study. Furthermore all individuals with active infection and malignancy were excluded. All laboratory data, U-II levels were analyzed. To prevent interobserver errors CIMT measurements were performed by a single radiologist

Results: There was no difference between the groups in terms of age, gender, smoking, dialysis duration. U-II levels were significantly higher only in HD group compared to PD and control groups. CIMT was significantly higher in both dialysis groups. Factors affecting CIMT were age in PD patients as well as glucose, albumin, phosphorus, PTH, IL-6, CRP, uric acid in HD patients. 

Conclusion: Although the role of U-2 in the development of atherosclerosis was demonstrated in experimental studies, no positive correlation was found between U-II and CIMT in current study. 

EISSN 2667-4440